Data sources include IBM Watson Micromedex (updated 1 Apr 2021), Cerner Multum™ (updated 5 Apr 2021), ASHP (updated 6 Apr 2021) and others. The cure rates, determined by the absence of eggs in stools, were 96, 93 and 74% at one, three and six months post-treatment for patients receiving a single dose (40 mg kg-1 body weight) of praziquantel, and 82, 78 and 78% for patients on a single dose (15 mg kg-1 body weight) of oxamniquine. oxamniquine oral ; Side Effects by Severity ; oxamniquine oral Generic Name(s): oxamniquine . It is generally well tolerated following oral doses. Oxamniquine is a potent single-dose agent for treatment of S. mansoni infection in man, and it causes worms to shift from the mesenteric veins to the liver, where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. Oral: 40 mg orally 2 times a day-Maximum dose: 240 mg/day Parenteral:-Initial dose: 80 mg via IV infusion every 12 hours, given over at least 2 minutes OR over 15 minutes-Maintenance dose: 80 mg via IV infusion every 8 to 12 hours, given over at least 2 minutes OR over 15 minutes The dosage of oxamniquine needed varies according to the geographic location where the infection was acquired (7). Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. In animal studies, pregnant animals were given this medication and had some babies Take oxamniquine exactly as directed by your doctor. Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. Oxamniquine may also be used for purposes other than those listed in this medication guide. Therefore, this medication may be used if the potential benefits to the mother outweigh Dosage. the potential risks to the unborn child. «Oxamniquine has been effective in some areas in which praziquantel is less effective (Stelma FF, et al: J Infect Dis 176:304, 1997). Use caution when driving, operating machinery, or performing other hazardous activities. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective. Cent Afr J Med. Recommended dose In 2 Phase III NVAF clinical trials, approximately 95% of ELIQUIS® (apixaban) patients received this dose. Revision Date: 2/13/04 4:02:18 PM. Side Effects. Myelography may identify discrete granulomatous masses that may be amenable to surgical removal (8). A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into … Do not take oxamniquine without first talking to your doctor if you are pregnant. abdominal pain, decreased appetite, or vomiting. CrCl . Oxamniquine is used for treatment of schistosomiasis. Find patient medical information for oxamniquine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. 48 (Group 1) were treated with a single oral dose of oxamniquine (20mg/kg body-weight) and 43 (Group 2) received the placebo. The FDA categorizes medications based on safety for use during pregnancy. Oral oxamniquine at a total dose of 60 mg/kg (given in 4 equal doses morning and evening over 2 days, after food) is an efficient and apparently very safe drug for the treatment of Schistosoma mansoni infections. The Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Ferrari,1 P.M.Z. The Oxamniquine dose your doctor recommends will be based on the following (use any or all that apply): the condition being treated other medical conditions you have other medications you are taking how you respond to this medication your weight your height your age your gender Select one or more newsletters to continue. 1986 Jul;32(7):165-7. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. Dosage Oral, 15 mg per kg of body weight two times a day for one day. Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment. Ask your doctor or pharmacist for more information. It is also not known whether oxamniquine passes into breast milk and how it might affect a nursing baby. This is an uncommon infection usually acquired through contact with freshwater in Africa. Tavares,4 & A.S. da Cunha5 Objective To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide Currently, praziquantel is the only drug used for treatment of all five species of human schistosomes. Other, less serious side effects may be more likely to occur. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Drug interactions with oxamniquine are not well known. A reddish discoloration of urine, probably due to a metabolite of oxamniquine, has been reported. You should consult with a medical professional if you have any questions about your health. Dosage Oral, 15 mg per kg of body weight two times a day for one day. Twenty patients (Group 1) were treated with a single oral dose of oxamniquine (15-20mg/kg body weight) and 15 (Group 2) were treated with cloramphenicol (50mg/kg body weight, for 15-20 days). In South America, adults are given 15 mg/kg of body weight as a single oral dose; in children 20 mg/kg is preferred, given in two divided portions each of 10 mg/kg with an interval of 4–6 h between doses. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Optimal dosage schedules vary for different regions of the world. Oxamniquine is used only to treat infections caused by the worm Schistosoma mansoni. About 70% of a dose of oxamniquine is excreted as the 6-carboxy metabolite within 12 hours of a dose; traces of the 2-carboxy metabolite have also been detected in the urine. Rarely, seizures have occurred, most often in patients who already have epilepsy or another seizure disorder. Your pharmacist has more information about oxamniquine written for health professionals that you may read. Take oxamniquine with food to lessen stomach upset. Oxamniquine should be given to a pregnant woman only if clearly needed. Take each dose with a full glass of water. 250 mg capsules. Treat to maintain ICP less than 20 mmHg and CPP between 40 and 50 mmHg. It is generally well tolerated following oral doses. Usual Adult Dose for Zollinger-Ellison Syndrome. Oxamniquine may be found in some form under the following brand names: This is not a complete list of Oxamniquinedrug interactions. Ferrari,1 P.M.Z. Tavares,4 & A.S. da Cunha5 Objective To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide Individuals weighing less than 25 kg were treated with 20 mg/kg of oxamniquine syrup and others were given 12.5-15 mg/kg as capsules. Follow the directions on your prescription label carefully. Tell your doctor and pharmacist about all medicines you are taking, so that they can monitor your therapy for interactions. The defined daily dose is 1 gram (by mouth) Side effects. Back to top. Oxamniquine is used for treatment of schistosomiasis. The efficacy of the antischistosomal drugs praziquantel and oxamniquine was tested on four groups of Ethiopian sugar estate workers. Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. This study sought to compare the effectiveness and side effects of praziquantel versus oxamniquine in treating 200 patients with Schistosoma mansoni infection and praziquantel versus metrifonate in treating 100 patients with S. haematobium infection. You may need a lower dose or special monitoring if you have any of these conditions. Availability. Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. When split doses of these drugs were used, praziquantel achieved cure rates of 96, 95 and 89%, while the corresponding … No studies have been done in animals, and no well-controlled studies have been done in Hydroquinone derivative prepared in the presence of Aspergillus sclerotium.Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver. The use of oral oxamniquine syrup or capsule in controlling endemic Schistosomia mansoni was studied in 191 residents of Castro Alves, northeast Brazil. 250 mg capsules. Take oxamniquine exactly as prescribed by your doctor. Take oxamniquine with food to lessen stomach upset. Search for more papers by this author. Availability. Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. Abdominal pain (4-21%) Cough (14-25%) Depression (undefined) Diarrhea (19-42%) Dyspnea (15-21%) Fever (14-40%) Headache (16-31%) Infection (18-22%) Insomnia (10-19%) Myalgia (undefined) Nausea (21-32%) Rash (22-46%) Rhinitis (5-24%) Vomiting (14-22%) Weakness (8-31%) VANSIL (Oxamniquine) David Schlossberg MD, FACP, FIDSA, FCPP. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Available for Android and iOS devices. Before taking oxamniquine, tell your doctor about any other medical conditions that you have, especially liver disease, kidney disease, or a seizure disorder. The Oxamniquine dose your doctor recommends will be based on the Generic Name: oxamniquine (ox AM ni kwin)Brand Name: Vansil. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into … Store oxamniquine at room temperature away from moisture and heat. Seek medical attention in the case of a seizure. de V Clarke V, Blair DM, Weber MC, Garnett PA. What happens if I miss a dose? In northern and southern Africa, standard schedules are 15 mg/kg twice daily for 2 days. to an unborn baby when a medication is taken during pregnancy. In geriatric patients, cautious dose selection is necessary because of decreased hepatic/renal/cardiac function and increased systemic exposure to cycloguanil; Dosing Modifications. Dosage. According to one systematic review, praziquantel is the standard treatment for S. mansoni infections and oxamniquine also appears effective. Side effects other than those listed here may also occur. Copyright 1996-2021 Cerner Multum, Inc. The use of any information on this site is solely at your own risk. Quinoline derivatives and related substances. Version: 3.03. Hydroquinone derivative prepared in the presence of Aspergillus sclerotium.Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver. 2 to 10 mL/kg/dose IV administered over 5 to 30 minutes; larger doses (e.g., 10 mL/kg/dose) require the upper end of the infusion range. This medication may be prescribed for other uses. Infants, Children, and Adolescents. It prevents worms from growing or multiplying in your body. Oxamniquine is con-traindicated in pregnancy. pregnant women. In the western hemisphere and western Africa, the adult oxamniquine dosage is 12–15 mg/kg given once. A reddish discoloration of urine, probably due to a metabolite of oxamniquine, has been reported. Dosage trial of a combination of oxamniquine and praziquantel in the treatment of schistosomiasis in Zimbabwean schoolchildren. Ninety-one children with chronic schistosomiasis mansoni were selected for this double blind trial. Ask your doctor or pharmacist for more information. Oxamniquine is available with a prescription under the brand name Vansil in 250 mg capsules. Five categories - A, B, C, D, and X, are used to classify the possible risks It is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Coelho,2 C.M.F. Tell your doctor if you are pregnant or plan to become pregnant. Oxamniquine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. Do not take oxamniquine without first talking to your doctor if you are breast-feeding a baby. Actions. Infuse appropriate dose at a rate to ensure that the entire dose is given before 10% or more of the drug is inactivated by the IV solution. Side Effects by Likelihood and Severity . Praziquantel and oxamniquine were given in single doses of 40 mg/kg body weight and 25 mg/kg, respectively. following (use any or all that apply): Oxamniquine is available in the following doses: Oxamniquine is available in the following forms: Enter multiple addresses on separate lines or separate them with commas. born with problems. JTriclabendazole may be effective in a dosage of 5 mg/kg once/day X 3 days or 10 mg/kg bid X 1 day (Calvopina M, et al: Trans R Soc Trop Med Hyg 92:566, 1998). Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. There are no well-controlled studies that have been done in pregnant women. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Steroids are used to suppress the host response around the ectopic eggs (5,6). Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoniinfection: a controlled trial M.L.A. 2 to 10 mL/kg/dose IV administered over 5 to 30 minutes; larger doses (e.g., 10 mL/kg/dose) require the upper end of the infusion range. Although oxamniquine and metrifonate have been used for schistosomiasis control, they are only effective against Schistosoma mansoni and S. haematobium, respectively. Clinical, laboratory and radiological examinations were performed before and after treatment. In northern and southern Africa, standard schedules are 15 mg/kg twice daily for 2 days. Stop taking oxamniquine and seek emergency medical attention if you experience an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives). Seek emergency medical attention or call a poison control center near you. Oxamniquine is usually taken in one or two doses that completely treat the infection. Other brand or generic formulations may also be available. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.