Int J Womens Health. From a yield of 205 papers based on titles alone, 58 papers, reporting results from 46 originator studies conducted in pregnant populations, constituted the initial evidence base. Systematic review of exposure to albendazole or mebendazole during pregnancy and effects on maternal and child outcomes, with particular reference to exposure in the first trimester Article May 2019 Careers. Systematic review of exposure to albendazole or mebendazole during pregnancy and effects on maternal and child outcomes, with particular reference to exposure in the first trimester. Siles-Lucas M, Casulli A, Cirilli R, Carmena D. PLoS Negl Trop Dis. Gyorkos TW, Larocque R, Casapia M, Gotuzzo E. Pediatr Infect Dis J. J Obstet Gynecol Neonatal Nurs. I'm generally quite chilled about medication in pregnancy but this would make me a bit antsy even with that study result. Effects of deworming on child and maternal health: a literature review and meta-analysis. doi: 10.1371/journal.pntd.0001417. Interpretation Mebendazole therapy during pregnancy is not associated with a significant increase in major congenital defects, but our results indicate that it should be avoided during the first trimester. The available evidence suggests no difference in congenital anomalies in the children of women who were treated with mebendazole during … No additional risk of adverse birth outcomes was found with first trimester exposure. Based on this cumulative evidence, it is unlikely that inadvertent exposure to albendazole or mebendazole in the first trimester carries an additional risk of adverse birth outcomes. Patients should be informed of the potential risk to the fetus in women taking mebendazole during pregnancy, especially during the first trimester (See Pregnancy ). JAMA. This drug is considered a Category B3 medication. Mebendazole therapy during pregnancy is not associated with a significant increase in major congenital defects, but our results indicate that it should be avoided during the first trimester. Studies that included around 1,650 women taking mebendazole during the first trimester of pregnancy found that these women do not seem to have a higher chance of having a baby with a birth defect. Keywords: There are number of international studies in pregnant women which have shown that there is no adverse effect of mebendazole on pregnancy or birth outcome15,16,17,18. ... small sample size or exclusion of first trimester mebendazole exposures. There was a trend toward an increase in defects among women who took the drug against recommendations during the first trimester, but this did not reach significance. 2005 Sep;45(3):85-8. doi: 10.1111/j.1741-4520.2005.00072.x. The rate of major congenital defects was not significantly higher in the mebendazole group than in the control group (97 [1.8%] of 5275 vs 26 [1.5%] of 1737; odds ratio 1.24 [95% CI 0.8-1.91], p=0.39). 2008 Apr 23;299(16):1937-48. doi: 10.1001/jama.299.16.1937. Studies of a small number of pregnant women taking mebendazole in early pregnancy have shown no link with miscarriage. Approximately 16% of respondents indicated that paramomycin was the safest medication to use in the first trimester of pregnancy. 2006 Oct;11(10):1485-95. doi: 10.1111/j.1365-3156.2006.01706.x. •. This site needs JavaScript to work properly. Current Resources for Evidence-Based Practice, July 2020. Evidence on exposure to albendazole or mebendazole in pregnancy is heterogeneous. Maternal Hookworm Infection and Its Effects on Maternal Health: A Systematic Review and Meta-Analysis. Children below the age of 1 year and pregnant women in the first trimester of pregnancy are not eligible for treatment [13]. 2017 Aug;116(8):2271-2276. doi: 10.1007/s00436-017-5533-8. ... Major congenital defects were not increased in women who took mebendazole after the first trimester. Among the nine originator observational studies which had included women in the first trimester of pregnancy within their study population, five compared birth outcomes between women exposed in the first trimester with women who were not exposed, and none reported higher rates of adverse birth outcomes in the exposed group. Mebendazole and Pregnancy Outcomes. Lancet Infect Dis. Mebendazole therapy during pregnancy is not associated with a significant increase in major congenital defects, but our results indicate that it should be avoided during the first trimester. Accessibility 2016 Nov 11;8:651-661. doi: 10.2147/IJWH.S103529. This therapy could offer beneficial effects to pregnant women in developing countries, where intestinal helminthiases are … Mebendazole and Pregnancy Outcomes. Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial. Helminth infection during pregnancy: insights from evolutionary ecology. •. Prevention and treatment information (HHS). Population-based case-control study of mebendazole in pregnant women for birth outcomes. Epub 2012 Jan 3. Untreated soil-transmitted helminth infections in pregnancy are associated with adverse outcomes (including maternal iron deficiency anemia, low birth weight, neonatal and maternal death). Treatment with topical miconazole during the first trimester did not increase the risk of congenital abnormalities (OR 0.9, range 0.6–1.6), 64 but combined vaginal metronidazole and miconazole therapy may be associated with a slight increase in polydactily or syndactily (OR 1.2, range 1.0–1.3). This was confirmed in a controlled prospective study, where 192 pregnancy outcomes were evaluated and compared with a matched control group (Diav-Citrin 2003). STUDY DESIGN: The Israeli Teratogen Information Service prospectively collected and followed 192 pregnancies exposed to mebendazole in pregnancy, 71.5% of whom had first-trimester exposure. Although WHO recommends that women of reproductive age, including pregnant women after the first trimester, be included in large-scale deworming programs, there are concerns related to the use of anthelminthic drugs during pregnancy, especially inadvertent use in the first few weeks when the pregnancy may not yet be confirmed. Where STH endemicity ≥20%, the World Health Organization (WHO) recommends preventive chemotherapy with single dose anthelminthic drugs: albendazole or mebendazole. in the first trimester of pregnancy (1,2). Would you like email updates of new search results? We assessed the effect of mebendazole therapy during pregnancy on birth outcome. Animal Data. To optimize relevance for policy making, future research in pregnant populations should aim to provide data disaggregated by trimester and to report on maternal and child adverse events, whenever possible. 2006 May-Jun;97(3):222-4. doi: 10.1007/BF03405590. Mebendazole is not recommended for use under 1 year of age. ... Major congenital defects were not increased in women who took mebendazole after the first trimester. Mebendazole is in pregnancy category C. Data on the use of mebendazole in pregnant women are limited. In view of these findings the use of mebendazole is not recommended in pregnant women. At present, however, this is not a widely accepted control strategy because of a lack of data on the safety of the drug. But mebendazole is considered category C pregnancy drug. However, an increased risk of congenital malformations was not observed in a study of over 400 pregnant women exposed to mebendazole in the first trimester (de Silva 1999). Two billion people are estimated to be infected with schistosomes and geohelminths, and mass deworming programs are widely advocated [1]. Studies that included around 1,650 women taking mebendazole during the first trimester of pregnancy found that these women do not seem to have a higher chance of having a baby with a birth defect. Clipboard, Search History, and several other advanced features are temporarily unavailable. A cross-sectional study was done in Sri Lanka, where prescription of mebendazole to women in the second trimester of pregnancy is recommended. Unable to load your collection due to an error, Unable to load your delegates due to an error. Would you like email updates of new search results? eCollection 2016. Privacy, Help Mebendazole For the control of threadworms a single 100mg dose of mebendazole should be administered but a second 100mg dose is recommended after two weeks, if re-infection is suspected (5). Probably better to avoid in first trimester at least as that is the most vulnerable time for birth defects. Studies on vertical transmission of Trichinella spiralis in experimentally infected guinea pigs (Cavia porcellus). Albendazole [19] and mebendazole [20] display a broad spectrum of activity and are administered orally, usually at a single dose of 400 mg and 500 mg, respectively [13,18,21]. Highlights. This site needs JavaScript to work properly. Soil-transmitted helminth infections cause an important burden of morbidity worldwide, primarily from blood loss and malabsorption of nutrients. Albendazole; First trimester; Mebendazole; Pregnancy; Soil-transmitted helminths. Interpretation: In view of these findings the use of mebendazole is not recommended in pregnant women. The World Health Organization (WHO) supports use of mebendazole after the first trimester. Epub 2017 Jun 19. Pregnancy outcome was compared with that of a matched control group, who were counseled for nonteratogenic exposure. Accessibility Unable to load your collection due to an error, Unable to load your delegates due to an error. The date of redemption of a prescription for mebendazole or pyrvinium was used to identify exposure, which was classified according to first, second, and third trimester. 2. Studies of a small number of pregnant women taking mebendazole in early pregnancy have shown no link with miscarriage. Embryo-fetal developmental toxicity studies in rats revealed no adverse effects on dams or their progeny at doses up to 2.5 mg/kg/day on gestation days 6-15 (the period of organogenesis). 2020 Nov;103(5):1958-1968. doi: 10.4269/ajtmh.20-0503. Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa. Although there are no adequate and well-controlled studies in pregnant women, a postmarketing survey has been done of a limited number of women who inadvertently had consumed mebendazole during the first trimester of pregnancy. If the infection is compromising the pregnancy (i.e. In the treatment of threadworm/pinworm in pregnancy, mebendazole could be considered after first attempting rigorous hygiene measures. Moreover, detrimental effects of helminths on maternal anemia, fetal growth, and infant mortality have … There was a trend toward an increase in defects among women who took the drug against recommendations during the first trimester, but this did not reach significance. 2018 May 13;6(5):901-907. doi: 10.3889/oamjms.2018.143. 2012 Jan;6(1):e1417. Pregnancy Risk Summary. Information for Patients. Mebendazole therapy during pregnancy is not associated with a significant increase in major congenital defects, but our results indicate that it should be avoided during the first trimester. Lack of risk of adverse birth outcomes after deworming in pregnant women. Trop Med Int Health. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. Antenatal Deworming and Materno-Perinatal Outcomes in Calabar, Nigeria. Careers. Published by Elsevier Ltd. National Library of Medicine A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru. Riva E, Fiel C, Bernat G, Muchiut S, Steffan P. Parasitol Res. Animal Data. In view of these findings the use of mebendazole is not recommended in pregnant women. COVID-19 is an emerging, rapidly evolving situation. 2017 Nov 7;17(Suppl 4):830. doi: 10.1186/s12889-017-4747-0. Epub 2015 Jan 12. Among 407 women who had taken mebendazole in the first trimester (contrary to medical advice), 10 (2.5%) had major congenital defects (odds ratio vs controls 1.66 [0.81-3.56], p=0.23). Privacy, Help The date of redemption of a prescription for mebendazole or pyrvinium was used to identify exposure, which was classified according to first, second, and third trimester. We compared the rates of major congenital defects, stillbirth, perinatal death, and low birthweight (< or = 1500 g) among babies of mothers who had taken mebendazole during pregnancy with those whose mothers had not taken an anthelmintic (controls). Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR. Two hospitals were chosen for the study, and women who gave birth there between May, 1996, and March, 1997, were recruited. 2006 Sep;25(9):791-4. doi: 10.1097/01.inf.0000234068.25760.97. FOIA In areas endemic for hookworm, routine antenatal mebendazole therapy could greatly reduce the prevalence of anaemia in pregnancy. Studies of a small number of pregnant women taking mebendazole in early pregnancy have shown no link with miscarriage. Background: Should deworming be included in antenatal packages in hookworm-endemic areas of developing countries? The date of redemption of a prescription for mebendazole or pyrvinium was used to identify exposure, which was classified according to first, second, and third trimester. 2012 Dec;12(12):942-9. doi: 10.1016/S1473-3099(12)70222-0. Epub 2020 Jun 20. Based on this cumulative evidence, it is unlikely that inadvertent exposure to albendazole or mebendazole in the first trimester carries an additional risk of adverse birth outcomes. In view of these findings the use of Mebendazole is not recommended in pregnant women. Clipboard, Search History, and several other advanced features are temporarily unavailable. eCollection 2018 May 20. Although WHO recommends that women of reproductive age, including … Pregnancy Risk Summary. Although there are no adequate and wellcontrolled studies in pregnant women, a post-marketing survey has been done of a limited number of women who inadvertently had consumed mebendazole during the first trimester of pregnancy. Where STH endemicity ≥20%, the World Health Organization (WHO) recommends preventive chemotherapy with single dose anthelminthic drugs: albendazole or mebendazole. Patients should also be informed that cleanliness is important to prevent reinfection and transmission of the infection. 8600 Rockville Pike eCollection 2018 Apr. 8600 Rockville Pike This therapy could offer beneficial effects to pregnant women in developing countries, where intestinal helminthiases are endemic. Although there are no adequate and well-controlled studies in pregnant women, a postmarketing survey has been done of a limited number of women who inadvertently had consumed mebendazole during the first trimester of pregnancy. National Library of Medicine This therapy could offer beneficial effects to pregnant women in developing countries, where intestinal helminthiases are endemic. Pregnancy outcome was compared with that of a matched control group, who were counseled for nonteratogenic exposure. COVID-19 is an emerging, rapidly evolving situation. •. Risks and benefits of treatment should be weighed carefully before giving these drugs during pregnancy, particularly during the first trimester. Future research should report benzimidazole exposure by trimester. Akpan UB, Asibong U, Okpara HC, Monjok E, Etuk S. Open Access Maced J Med Sci. This therapy could offer beneficial effects to pregnant women in developing countries, where intestinal helminthiases are endemic. doi: 10.1371/journal.pntd.0006422. Introduction. Bethesda, MD 20894, Copyright Pregnancy should be considered as a condition with increased vulnerability to infections, including some life-threatening fungal infections, but paradoxically little is known regarding optimal antifungal regimens and dosages in this setting. Bethesda, MD 20894, Copyright FOIA Congenit Anom (Kyoto). Soil-transmitted helminth infections cause an important burden of morbidity worldwide, primarily from blood loss and malabsorption of nutrients. Untreated soil-transmitted helminth infections in pregnancy are associated with adverse outcomes, including maternal iron deficiency anemia, low birth weight, and neonatal and maternal death. Previously, deworming has been avoided during pregnancy and lactation because of safety concerns; however, in areas where women are pregnant or lactating for over half of their reproductive lives, this may result in treatment delays and morbidity [2]. So The number of women redeeming a prescription for a drug 0–3 months after pregnancy was 104 for pyrvinium, 2559 for mebendazole, and 40 for both drugs. Studies that included around 1,650 women taking mebendazole during the first trimester of pregnancy found that these women do not seem to have a higher chance of having a baby with a birth defect. Mebendazole had teratogenic effects in some animal studies. 2015 Mar;15(3):277-84. doi: 10.1016/S1473-3099(14)71050-3. Due to heterogeneity in terms of study design, sample size, deworming drug, dosage and outcomes measured, data from these studies could not be pooled. Conflicting results of several case reports and (retrospective) studies in hundreds of human pregnancies (including many first-trimester exposures) do not allow a well-founded estimation of human risk. BMC Public Health. Gyorkos TW, Larocque R, Casapia M, Gotuzzo E. Pediatr Infect Dis J. ... small sample size or exclusion of first trimester mebendazole exposures. It is best not to be used in pregnancy, especially in the first trimester. The number of women redeeming a prescription for a drug 6–9 months before pregnancy was 32 for pyrvinium, 2320 … Based on this cumulative evidence, it is unlikely that inadvertent exposure to albendazole or mebendazole in the first trimester carries an additional risk of adverse birth outcomes. Speich B, Ali SM, Ame SM, Bogoch II, Alles R, Huwyler J, Albonico M, Hattendorf J, Utzinger J, Keiser J. Lancet Infect Dis. Epub 2012 Sep 18. Lack of risk of adverse birth outcomes after deworming in pregnant women. 2018 Apr 20;12(4):e0006422. Copyright © 2019. first trimester, have been found to be safe and effective, having few and minor, if any, side effects12,13,14.. Prevention and treatment information (HHS). 2006 May-Jun;97(3):222-4. doi: 10.1007/BF03405590. From anticipating the day you'll bring your little one home, to picking a name and nursery colors, the excitement is palpable. Prevention and Control of Anaemia in Pregnancy, which formally recommends that mebendazole is given to all pregnant women after their first trimester; without routine stool examination through government antenatal c l i n i c s .1 4 Mebendazole is also available over the counter from pharmacies, without prescription, and at low cost. Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. There are limited published data on the use of mebendazole during pregnancy; such use is contra-indicated by Please enable it to take advantage of the complete set of features! Breastfeeding should not be withheld during mebendazole therapy. Findings: Although there are no adequate and well-controlled studies in pregnant women, a post-marketing survey has been done of a limited number of women who inadvertently had consumed mebendazole during the first trimester of pregnancy. Please enable it to take advantage of the complete set of features! The further along you are the less bothered I'd be in your shoes. When used in the treatment for hookworm, and if required during the first trimester, the benefit of treatment with mebendazole may outweigh any risk. Can J Public Health. Embryo-fetal developmental toxicity studies in rats revealed no adverse effects on dams or their progeny at doses up to 2.5 mg/kg/day on gestation days 6-15 (the period of organogenesis). Methods: This means its safety for use in pregnancy has not been established. Soukhathammavong PA, Sayasone S, Phongluxa K, Xayaseng V, Utzinger J, Vounatsou P, Hatz C, Akkhavong K, Keiser J, Odermatt P. PLoS Negl Trop Dis. Gyorkos TW, St-Denis K Int J Parasitol 2019 Jun;49(7):541-554. STUDY DESIGN: The Israeli Teratogen Information Service prospectively collected and followed 192 pregnancies exposed to mebendazole in pregnancy, 71.5% of whom had first-trimester exposure. Am J Trop Med Hyg. Ness TE, Agrawal V, Bedard K, Ouellette L, Erickson TA, Hotez P, Weatherhead JE. We therefore conducted a systematic review using the MEDLINE database with the aim of appraising all peer-reviewed evidence, published up to July 1, 2018, on the association between exposure to albendazole or mebendazole and outcomes in pregnant women, including those in the first trimester of pregnancy, and their children. Mebendazole therapy during pregnancy is not associated with a significant increase in major congenital defects, but our results indicate that it should be avoided during the first trimester. 2006 Sep;25(9):791-4. doi: 10.1097/01.inf.0000234068.25760.97. Having a baby is one of the most joyous times in many women's lives. To optimize relevance for policy making, future research in pregnant populations should aim to provide data disaggregated by trimester and to report on maternal and child adverse events, whenever possible. Preventive chemotherapy (deworming), using single-dose albendazole (400 mg) or mebendazole (500 mg), is recommended as a public health intervention for pregnant women, after the first trimester, living in areas where both: (i) the baseline prevalence of hookworm and/or T. trichiura infection is 20% or more among pregnant women, and (ii) where anaemia is a severe public health problem, with a prevalence of 40% or higher among pregnant … Mebendazole is a synthetic anthelmintic agent that is structurally related to albendazole and thiabendazole. Should deworming be included in antenatal packages in hookworm-endemic areas of developing countries? The proportions of stillbirths and perinatal deaths were significantly lower in the mebendazole group (1.9 vs 3.3%, 0.55 [95% CI 0.4-0.77]), as was the proportion of low-birthweight babies (1.1 vs 2.3%, 0.47 [95% CI 0.32-0.71]). Based on this cumulative evidence, it is unlikely that inadvertent exposure to albendazole or mebendazole in the first trimester carries an additional risk of adverse birth outcomes. In view of these findings the use of mebendazole is not recommended in pregnant women. Eisele TP, Larsen DA, Anglewicz PA, Keating J, Yukich J, Bennett A, Hutchinson P, Steketee RW. 2020 Jul;49(4):391-404. doi: 10.1016/j.jogn.2020.06.002. Larocque R, Casapia M, Gotuzzo E, MacLean JD, Soto JC, Rahme E, Gyorkos TW. Can J Public Health. Interpretation: Mebendazole therapy during pregnancy is not associated with a significant increase in major congenital defects, but our results indicate that it should be avoided during the first trimester. weight loss, sleeplessness) then treatment can be considered, but should be withheld until the 3rd trimester when the risk, if any, to the fetus is likely to be reduced. There are no controlled data in human pregnancy; however, this drug has been used during pregnancy without evidence of fetal harm. Although there are no adequate and well-controlled studies in pregnant women, a postmarketing survey has been done of a limited number of women who inadvertently had consumed Mebendazole during the first trimester of pregnancy. If a woman in her first trimester of pregnancy is found to have ascariasis, she must wait until the second trimester to receive treatment. Can I take mebendazole in pregnancy?

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