DO NOT perform dose conversion when using a U-500 insulin syringe. This could cause severe overdose and may lead to death. Available data from published literature suggests that exogenous human insulin products, including HUMULIN R, are transferred into human milk. Severe hypoglycemia can cause seizures, may be life-threatening or cause death. Tap the Cartridge Holder gently to collect air bubbles at the top. You can give from 5 to 300 units in a single injection. Make sure you know how to draw up your dose with a U-500 syringe. So instead of the typical U-100 insulin (100 units/ml), U-500 insulin is 500 units/ml—5x as concentrated. There are no adverse reactions reported in breastfed infants in the literature. 500 syringes with other people. When using HUMULIN R U-500 from a vial, patients should be counseled to use only a U-500 insulin syringe and be informed that no dose conversion is required [see Dosage and Administration (2.4)]. The timing of hypoglycemia usually reflects the time-action profile of the administered insulin formulation. If you use another kind of syringe, you may get a dangerous overdose. If you click "I Disagree" you can still use this website. have an allergy to human insulin or any of the ingredients in Humulin R U-500. This is especially important if you use more than 1 type of insulin. Use Humulin R U-500 exactly as your healthcare provider tells you to. ©Lilly USA, LLC 2020. Instruct patients to inject HUMULIN R U-500 subcutaneously usually two or three times daily approximately 30 minutes before meals. Advise patients who have repeatedly injected into areas of lipodystrophy or localized cutaneous amyloidosis to change the injection site to unaffected areas and closely monitor for hypoglycemia. Instruct patients to always check the insulin label before administration to confirm the correct insulin product is being used. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. The signs and symptoms of hypoglycemia [see Warnings and Precautions (5.4)] may be blunted when beta-blockers, clonidine, guanethidine, and reserpine are co-administered with HUMULIN R U-500. Refer patients to the HUMULIN R U-500 Patient Information Leaflet for additional information [see Warnings and Precautions (5)]. Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500. In elderly patients with diabetes, the initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemia. Humulin R U-500 is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day. You may give other people a serious infection or get a serious infection from them. People who are blind or have vision problems should not use the Pen without help from a person trained to use the Pen. Humulin U-500 Conversion Chart Mar 2011 U-500 is specifically for people like you – people whose A1C levels are above their target even though they’ve been taking more than 200 units of insulin each day. Inject your insulin exactly as your healthcare provider has shown you. You may give other people a serious infection or get a serious infection from them. Common Brand(s): Humulin R Concentrated insulin regular is used with a proper diet and exercise program to control high blood sugar in people with diabetes who require large doses of insulin (more than 200 units per day). Do not use any other type of syringe to administer Humulin R U-500. By clicking "I Agree" you consent to our use of tracking technologies and disclosure of tracking data to third party ad networks or social media companies for the purposes above. HUMULIN® R U-500 KwikPen®, insulin human injection U-500 (500 units/mL, 3 mL single-patient-use pen). The markings in the Dose Window may not be the same as the markings on the syringe you used in the past. Instruct patients using the vial presentation to use only a U-500 insulin syringe and on how to correctly draw the prescribed dose of HUMULIN R U-500 into the U-500 insulin syringe. 3 mL single-patient-use HUMULIN R U-500 KwikPen (containing 1,500 units of insulin), 20 mL multiple-dose vial (containing 10,000 units of insulin). It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins. If hypersensitivity reactions occur, discontinue HUMULIN R U-500; treat per standard of care and monitor until symptoms and signs resolve [see Adverse Reactions (6)]. Read Humulin®R U-500 KwikPen® Instructions for Use. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating. Generic Name: insulin human Dosage Form: injection, solution Indications and Usage for Humulin R U-500 HUMULIN R U-500 is a concentrated human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus requiring more than 200 units of insulin per day. Detailed Information The prefilled U-500R Pen What is Humulin R U-500 (Concentrated)? This can lead to severe breathing problems, irregular heartbeat, and death. Please see Instructions for Use included with the pen. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Each line on the U-500 syringe measures 5 units of U-500 insulin. Marketed by: Lilly USA, LLC, Indianapolis, IN 46285, USA. The following adverse reactions are discussed elsewhere: The following additional adverse reactions have been identified during post-approval use of HUMULIN R U-500. Frequent glucose monitoring and insulin dose reduction may be required in patients with renal impairment. This is normal. Not actual patients or healthcare providers. This information does not take the place of talking with your doctor. Metabolism — The uptake and degradation of insulin occurs predominantly in liver, kidney, muscle, and adipocytes, with the liver being the major organ involved in the clearance of insulin. Erratum, 2016;22(7):905, Study conducted with U-100 insulin syringes and Humulin R U-500 vials, In a clinical study, U-500 was shown to lower A1C by an average of 1.1% points in people who were not well controlled on more than 200 units of standard U-100 insulin a day.ǂ. Humulin R U 500 Coupons - Updated Daily 2021. Store unopened vials in the refrigerator. Store in a refrigerator (36° to 46°F [2° to 8°C]), but not in the freezer. If there are air bubbles, tap the syringe gently a few times. Do not use if it has been frozen. Instruct patients to always check the insulin label before each injection. If it has been frozen, do not use it. The markings on the U-500 insulin syringe show the number of units of HUMULIN R U-500 to be injected. Always use a new needle when injecting Humulin R U-500. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Check your insulin label each time you give your injection to make sure you are using the correct insulin. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively. Insulin, including HUMULIN R U-500, may cause sodium retention and edema, particularly if previously poor metabolic control is improved by intensified insulin therapy. HUMULIN R U-500 KwikPen meets the current dose accuracy and functional requirements of ISO 11608-1. If your dose is more than 300 units, you will need to give more than 1 injection. Any allergies you have. Excess insulin administration may cause hypoglycemia and hypokalemia. Human insulin is produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Humulin N, Humalog, metformin, Trulicity, Lantus, Victoza, Tresiba, Levemir, Novolog, Basaglar. The prescribed dose of HUMULIN R U-500 should always be expressed in units of insulin [see Dosage and Administration (2.4)]. Switching from HUMULIN R U-500 vial (and syringe). You can give from 5 to 300 units in a single injection. The time action characteristics reflect both prandial and basal activity, consistent with clinical experience. Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use). •If you use another kind of syringe, you may get a dangerous overdose. Your email address will not be saved or stored. Your Pen may measure your dose differently. It dials. Always carry an extra Pen in case yours is lost or damaged. Humulin R U-500 may cause serious side effects that can lead to death, including: severe allergic reaction (whole body reaction). Ask your pharmacist for an accurate price at time of sale. Be sure to include the over-the-counter medicines, vitamins, and herbal supplements you take. Lilly USA, LLC is not responsible for the privacy policy of any third-party websites. Do not use if it has been frozen. Weight gain can occur with insulin therapy, including HUMULIN R U-500, and has been attributed to the anabolic effects of insulin. See storage table below: Not In Use (Unopened) HUMULIN R U-500 Vials. Do not drive or use heavy machinery until you know how Humulin R U-500 affects you. • Humulin R U-500 is useful for the treatment of insulin-resistant patients with diabetes requiring daily doses of more than 200 units, since a large dose may be administered subcutaneously in a reasonable volume. Use only a U-500 insulin syringe with HUMULIN R U-500 to avoid administration errors. Any medical conditions, including problems with your liver, kidney, or heart. Humulin R U-500 (Concentrated) Coupons and Rebates Humulin R U-500 (Concentrated) offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. The most common side effects of Humulin R U-500 include: These are not all of the possible side effects of Humulin R U-500. Symptoms may be different for each person. you can give yourself a 5 times overdose. It comes in a 20-mL vial. HUMULIN R U-500 contains 500 units of insulin in each milliliter. Hypoglycemia is the most commonly observed adverse reaction in patients using insulin, including HUMULIN R U-500. Hypokalemia must be corrected appropriately. Inspect Humulin R U-500 visually for particulate matter and discoloration. REGULAR INSULIN (REG yuh ler IN su lin) is a human-made form of insulin. Read the instructions that come with your Humulin R U-500 carefully. Humulin R U-500 is a prescription insulin used in adults and children who need more than 200 units of insulin a day to control high blood sugar for their diabetes mellitus. Change (rotate) where you inject your insulin with each dose. Patients taking HUMULIN R U-500 may experience injection site reactions, including injection site hematoma, pain, hemorrhage, erythema, nodules, swelling, discoloration, pruritus, warmth, and injection site mass. Talk to your doctor about low blood sugar symptoms and treatment. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. Store the Pen you are currently using at room temperature up to 86°F (30°C). Inject Humulin R U-500 under the skin (subcutaneously) of your upper legs (thighs), upper arms, buttocks or stomach area (abdomen). Only use Humulin R U-500 if the solution appears clear and colorless. There are no data on the effects of exogenous human insulin products, including HUMULIN R on milk production. This will help you avoid infection. For more information on HUMULIN R U-500 KwikPen and insulin, go to www.humulin.com. Figure 1: Mean Insulin Activity Versus Time Profiles After Subcutaneous Injection of a 100 U Dose of HUMULIN R U-500 in Healthy Obese Subjects. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended. low blood sugar (hypoglycemia), allergic reactions including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), itching, and rash. Prescribe patients a U-500 insulin syringe to administer HUMULIN R U-500 from the vial to avoid administration errors. Humulin R U-500 is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day. Dosage Form: injection, solution. Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, and delivery complications. 2015;21(7):782-793. Ask your healthcare provider what your dose should be for your Pen in insulin units. Humulin R U-500 from vials should only be administered using U-500 syringes and patients should not be converting U-500 doses to U-100 syringes due to a high risk of potential adverse effects. Talk to your doctor about low blood sugar symptoms and treatment. The Humulin R U-500 KwikPen is available in a 2-pen pack, dials and doses up to 300 units/injection and contains 1500 units of insulin per pen. Copyright © 1996, 2019, Eli Lilly and Company. Prescribe HUMULIN R U-500 ONLY to patients who require more than 200 units of insulin per day. Your card is now activated and ready for use. Press the injection site lightly with a piece of gauze or an alcohol swab. Hold your Pen with the Needle pointing up. If stored at room temperature, below 86°F (30°C) the vial must be discarded after 40 days. U-500 is 5 times more concentrated than standard U-100 insulin. Always check the number in the Dose Window to make sure you have dialed the correct dose. Tell your doctor if you are pregnant or plan to become pregnant. Changing insulin may lead to low or high blood sugar. While available studies cannot definitively establish the absence of risk, published data from retrospective studies, open-label, randomized, parallel studies and meta-analyses over decades have not established an association with human insulin use during pregnancy and major birth defects, miscarriage, or adverse maternal or fetal outcomes. In contrast, Humulin R U-100 insulin is a short-acting, prandial insulin. Do not recycle your used sharps disposal container. Rotate insulin injections sites within the same region to reduce the risk of lipodystrophy [see Dosage and Administration (2.1)]. As with all therapeutic proteins, insulin administration may cause anti-insulin antibodies to form. Then your card will be ready to be shared with your specialty pharmacy. This strength contains 500 units of insulin per 1 mL of solution. Other syringes will not measure your dose correctly. The dose window of the HUMULIN R U-500 KwikPen shows the number of units of HUMULIN R U-500 to be injected and NO dose conversion is required. Hypoglycemia is the most common adverse reaction associated with insulin, including HUMULIN R U-500. Humulin® is a trademark of Eli Lilly and Company. Pull off the Paper Tab from the Outer Needle Shield. As with all insulin preparations, the glucose lowering effect time course of HUMULIN R U-500 may vary in different individuals or at different times in the same individual and depends on many conditions, including the area of injection as well as the injection site blood supply and temperature. Repeated insulin injections into areas of lipodystrophy or localized cutaneous amyloidosis have been reported to result in hyperglycemia; and a sudden change in the injection site (to an unaffected area) has been reported to result in hypoglycemia [see Adverse Reactions (6)]. Severe low blood sugar, which can lead to seizures, unconsciousness, and death. U-500 is an insulin that is taken 2 or 3 times per day. Select Safety Information for Humulin R U-500 If you still have questions, call The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). Your dose of Humulin R U-500 may need to change because of: What should I avoid while using Humulin R U-500? Always follow your healthcare provider's instructions for dosing. When using the Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. The effect of age on the pharmacokinetics and pharmacodynamics of HUMULIN R U-500 has not been studied. Instruct the patient to inform hospital or emergency department staff of the dose of HUMULIN R U-500 prescribed, in the event of a future hospitalization or visit to the emergency department. Humulin R (U-500) has had nothing added to change the speed or length of its action. Adhere to administration instructions [see Dosage and Administration (2.1, 2.4)]. Individualize and titrate the dosage of HUMULIN R U-500 based on the patient's metabolic needs, blood glucose monitoring results, and glycemic control goal. This lets the air bubbles rise to the top. Treatment with TZDs and Humulin R U-500 may need to be adjusted or stopped by your healthcare provider if you have new or worse heart failure. Copyright © 1997, 2019, Eli Lilly and Company. Humulin R U-500 is a concentrated insulin. The HUMULIN R U-500 KwikPen is different from other pens. HUMULIN R U-500 KwikPen (“Pen”) is a disposable single-patient-use prefilled pen containing 1500 units of HUMULIN R. You can give yourself more than 1 dose from the Pen. What you should know if you are switching to HUMULIN R U-500 KwikPen. Adjustments in drug dosage, meal patterns, or exercise may be needed. There may be new information. DO NOT TRANSFER TO A SYRINGE Push the capped Needle straight onto the Pen and twist the Needle on until it is tight. †Please see Instructions for Use included with your pen or click here. If you do not have a FDA-cleared sharps disposal container, you may use a household container that is: When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. The plunger will only reach the end of the cartridge when you have used all 1500 units in the Pen. Changes in an insulin regimen (e.g., insulin strength, manufacturer, type, injection site or method of administration) may affect glycemic control and predispose to hypoglycemia [see Warnings and Precautions (5.4)] or hyperglycemia. A severe overdose can happen, causing very low blood sugar, which may put your life in danger. This medicine lowers the amount of sugar in your blood. Disease-associated maternal and/or embryo/fetal risk. IMPORTANT: Use only with a U-500 syringe. For more information on Humulin R U-500 insulin, go to www.humulin.com, Dose Knob: Aqua with raised ridges on the end, Label: HUMULIN R U-500 and 500 units/mL in a green box, KwikPen compatible Needle (Becton, Dickinson and Company Pen Needles recommended).
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