This extended onset helps to lower the incidence of hypoglycemia (low blood sugar). Medication errors, such as accidental mix-ups between basal insulin products and other insulins, particularly rapid-acting insulins, have been reported. Continue reading >>, Dosage Forms & Strengths injectable solution 100 units/mL (Lantus; 10mL vial) 100 units/mL (Lantus SoloSTAR; Basaglar KwikPen; 3 mL disposable prefilled pens) 300 units/mL (Toujeo; 1.5 mL SolosStar disposable prefilled pen) Note: Recent studies have suggested that glargine-300 extends blood glucose control well beyond 24 hr Type 1 or 2 Diabetes Mellitus Lantus and Toujeo are recombinant human insulin analogs indicated to improve glycemic control in adults with type 1 or 2 diabetes mellitus Dosing Considerations Indicated for once-daily SC administration; exhibits relatively constant glucose-lowering profile over 24 hr May be administered at any time during the day; should be administered SC once daily at the same time every day Dose must be individualized based on clinical response; blood glucose monitoring is essential in all patients receiving insulin therapy Patients adjusting the amount or timing of dosage should do so only under medical supervision with appropriate glucose monitoring In patients with type 1 diabetes, insulin glargine must be used in regimens with short-acting insulin Should not be administered IV or via an insulin pump; IV administration of the usual SC dose could result in severe hypoglycemia As with all insulins, injection sites should be rotated within the same region (abdomen, thigh, or deltoid) from one injection to the next to reduce the risk of lipodystrophy; no clinically relevant difference in insulin glargine absorption after abdominal, deltoid, or thigh SC administration As with all insulins, the rate of absorption and, consequently, the onset and duration of action may be affected by exercise and other variables (eg, stress, intercurrent illness, changes in coadministered drugs, meal patterns) Type 1 diabetes mellitus: Starting dose sho (Toujeo) 6 hours No peak PK/PD profile slightly different from Lantus 24 hours Trial data indicates patients converting from Lantus may require higher doses of Toujeo, though initial conversion is 1:1. Lantus is the world’s most prescribed insulin. Do Simvastatin Side Effects Include Diabetes and Joint Pain? It delivers doses in 2-unit increments and can deliver up to 160 units in a single injection. Glargine (the insulin in both Lantus and Toujeo) is an insulin analoguemeaning it has been modified from regular insulin to change its structure and the way it is absorbed. Starting Dose in Insulin-Naïve Patients Type 1 Diabetes: The recommended starting dose of TOUJEO in insulin naïve patients with type 1 diabetes is approximately one-third to one-half of the total daily insulin dose. This basal insulin works by forming crystals inside the body, which gradually dissolve and release small amounts of insulin into the bloodstream over the course of 24 hours or longer (up to 36 hours). Source: BD Diabetes Healthcare BD is the leading brand of insulin syringes. T2DM is characterized by insulin resistance and progressive beta-cell dysfunction. Toujeo is contraindicated during episodes of hypoglycemia and in patients hypersensitive to insulin glargine or any of its excipients. It is recommended for patients requiring at least 20 units per day. I would recommend consulting with your doctor on how to start out with Toujeo and how to adjust to a proper dose. New comments cannot be posted and votes cannot be cast. How on earth does this all work?! Insulin is classically prescribed at a very specific concentration called U-100. TOUJEO et LANTUS n'étant pas bioéquivalents, ils ne sont donc pas directement interchangeables :. Conversions for inhaled insulin are discussed here - inhaled insulin dosing; Lantus, Semglee, Basaglar, Levemir, and Tresiba . once-daily Basaglar. The U.S. Food and Drug Administration late last week approved the once daily, long-acting basal insulin to treat type 1 and type 2 diabetes. Toujeo is more concentrated than Lantus and absorbs slower. Insulin glargine was introduced in the year 2000. Toujeo to Lantus conversion The dosing information for Toujeo recommends decreasing the total insulin dose to 80% of the daily requirement of Toujeo when switching from to Lantus, and that a higher total daily dose may be needed with Toujeo. Please note: the Federal Employee Health Benefits (FEHB) Program is not a federal or state government health care program for purposes of this savings program. The Toujeo label is probably going to be viewed as more undifferentiated than expected. is 80% of the total daily NPH insulin dosage. Continue reading >>, Early in 2015 the FDA approved the first concentrated long-acting insulin known as Toujeo (insulin glargine), and it’s now available in pharmacies. It delivers doses in 1 unit increments and can deliver up to 80 units in a single injection. The average retail price for 3 prefilled 1.5 mL pens of 300 units of insulin per mL of Toujeo (the most frequently filled prescription according to GoodRx data) is about $477. Meet the Toujeo ® pens. The safety and efficacy of Toujeo, given once daily, have been compared to Lantus given once daily in patients with type 1 or 2 diabetes mellitus. • During changes to a patient’s insulin regimen, increase the frequency of blood glucose monitoring [see Warnings and Precautions (5.2)]. Patients should be instructed to always verify the insulin label before each injection. Warnings and Precautions Toujeo® contains the same active ingredient, insulin glargine, as Lantus®. What do you think?? A subreddit for pharmacists, pharmacy students, techs, and anyone else in the pharmaceutical industry. ... DO NOT perform dose conversion when using the TRESIBA U-100 or U-200 pens. Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness to minimize the risk of hypoglycemia or hyperglycemia [see Warnings and Precautions (5.2), and Use in Specific Populations (8.5, 8.6)]. number of units of TOUJEO to be injected and no conversion is required. Upon registration, patients receive all program details. To minimize risk of hypoglycemia, you should dose reduce upon converting back to Lantus. Toujeo (insulin glargine) is an ultra long-acting type of insulin used for treating diabetes. Sanofi US reserves the right to change the maximum cap amount, rescind, revoke, or amend the p example: pt was on 200U of lantus, instead now you give 160U toujeo. 2 Insulin glargine (Lantus) to insulin detemir (Levemir) • Convert unit-per-unit. Thanks for the A2A. Contraindications Lantus® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to insulin glargine or one of its excipients. It is also used to tr All subjects received mealtime insulin along with their basal insulin. *This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicare, Medicaid, VA, DOD, TRICARE, or similar federal or state programs, including any state pharmaceutical programs. The biggest difference between the two basal insulins is that while Lantus contains 100 units/mL, Toujeo is more concentrated and triples Lantus' capacity, yielding 300 units/mL. Comparative Effectiveness and Costs of Insulin Pump Therapy for Diabetes, Economic Costs of Diabetes in the U.S. in 2012, Texting Helps Low-Income Diabetes Patients Manage Insulin Dosing, Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE). Welcome to /r/Pharmacy , a subreddit for pharmacists, pharmacy students, techs, and anyone else in the pharmaceutical industry! TOUJEO Max SoloStar contains 900 units of TOUJEO U-300. Don't worry, Wil's got this... {Have your own questions? Toujeo or Lantus was given either every morning or every evening for 26 weeks. The maximum glucose lowering effect of a dose of TOUJEO may take five days to fully manife Fast forward a decade and a half later, and insulin glargine (originally Lantus) has reinvented itself. is 80% of the Toujeo dose. The recommended starting dose of Lantus ® in patients with type 2 diabetes who are not currently treated with insulin is 0.2 Units/kg or up to 10 Units once daily, adjusted to patient’s appropriate FPG target. Hypoglycemia is the most common adverse reaction of insulin therapy, including Toujeo®, and may be life-threatening. Les deux sont fabriqués à partir d'insuline glargine et sont tout aussi efficaces pour réduire la glycémie. When changing from another basal insulin to Toujeo®, patients experienced higher average fasting plasma glucose levels in the first few weeks of therapy until titrated to their individualized fasting plasma glucose targets. Toujeo vs Lantus, Toujeo Costs, Insulin Glargine Doctablet Diabetes , Endocrinology , Everything About Insulin , Medicine Its understandable if you are wondering about the difference between Lantusand Toujeo. Email us at [email protected]} Matthew, type 2 from Oregon, asks: I’m confused about the new basal insulin Toujeo, I understand that it is U-300 and therefore should be more “concentrated,” but when I went to the webpage for this product, it talked about how Toujeo is a 1:1 dosing and conversion from Lantus. At the end of the trial, the reducti I still can't get over why they didn't call it Threejeo. Im switching and Im not sure if I am supposed to take the same number of units of Toujeo as I normally take with Lantus. Its onset is approximately six hours after injection, as opposed to the 1-2 hours for Lantus. Studies found that Toujeo’s overall ability to control blood sugar levels matched that of Lantus. Warnings and Precautions Insulin pens, needles, or syringes must never be shared between patients. Limitations of Use: Lantus® is not recommended for the treatment of diabetic ketoacidosis. Both Lantus and Toujeo contain insulin glargine. The 100 stands for the number of units present in the liquid (1 milliliter ). Toujeo is used to treat type 1 diabetes in adults and in children no younger than six years old. Let’s say you need to measure 400 units of Humulin R U-500 insulin. Individualize and titrate the dosage of TOUJEO based on the individual's metabolic needs, blood glucose monitoring results, and glycemic control goal. Some people think Tou The higher concentration means that patients can inject a lower volume of insulin. Savings may vary depending on patients’ out-of-pocket costs. Please consult your healthcare professional if you have any questions about your health or treatment. To minimize the risk of hypoglycemia, do not dilute or mix TOUJEO with any other insulin products or solutions. The most commonly prescribed insulins are referred to as “U100” insulin in which 100 units of insulin are suspended or dissolved in 1 mL of liquid. I also had it in my head that there was a U-60 at one time, but I may be wrong about that, as a quick Google search only turns up articles about the German Sub U-60, which apparently had one of the least distinctive war records of the Nazi fleet -- and no discussions of insulin. Toujeo vs Lantus, Toujeo Costs, Insulin Glargine Doctablet Diabetes , Endocrinology , Everything About Insulin , Medicine Its understandable if you are wondering about the difference between Lantusand Toujeo. Knowing that Toujeo is concentrated, you might think that you can take a much smaller amount of Toujeo for a similar dose compared to Lantus. 1:1 CONVERSION. While Toujeo is the first of its kind, the key word is “concentrated.” It actually contains the same active ingredient (insulin glargine) as Lantus—which is currently the #1 prescribed insulin in the US. Please see accompanying full Prescribing Information. Does anyone know why this is? As a general rule, 0.2 to 0.4 units of insulin per kilogram of body weight can be used to calculate the initial total daily insulin dose in insulin naïve patients with type 1 diabetes. Summary. Modify insulin regimens cautiously and only under medical supervision. Toujeo is a more potent follow-up to the drugmaker’s top-selling Lantus insulin product, which accounts for a fifth of Sanofi sales. Insulin release is triggered by an increase in blood glucose from food consumption. Anyway, back in the many-conce In controlled clinical studies comparing LANTUS to NPH insulin, 593 of 3890 patients (15%) with type 1 and type 2 diabetes were ≥65 years of age and 80 (2%) patients were ≥75 years of age.