Ethinyl Estradiol; Etonogestrel: (Minor) Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. Insulins are known to cause hypoglycemia. Ombitasvir; Paritaprevir; Ritonavir: (Moderate) Monitor patients receiving insulin closely for changes in diabetic control, specifically hyperglycemia, when anti-retroviral protease inhibitors are instituted. Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion. Insulin lispro protamine es una insulina de acción intermedia. Condizioni che possono determinare i sintomi premonitori dell’ipoglicemia differenti o meno evidenti, comprendono la lunga durata del diabete, l’intensificazione della terapia insulinica, la neuropatia. Hydrocortisone: (Moderate) Monitor patients receiving insulin closely for worsening glycemic control when corticosteroids are instituted and for signs of hypoglycemia when corticosteroids are discontinued. Insulina lispro agisce rapidamente e ha una durata d’azione più breve (2-5 ore) rispetto, Studi clinici in pazienti con diabete di tipo 1 e tipo 2 hanno dimostrato un’iperglicemia postprandiale. Salicylates, by inhibiting prostaglandin E2 synthesis, can indirectly increase insulin secretion. Niacin; Simvastatin: (Moderate) Monitor patients receiving insulin closely for changes in diabetic control when niacin, niacinamide is instituted or discontinued. Ethanol inhibits gluconeogenesis, which can contribute to or increase the risk for hypoglycemia. Also, adrenergic medications may decrease glucose uptake by muscle cells. Salicylates, by inhibiting prostaglandin E2 synthesis, can indirectly increase insulin secretion. After acute overdose, aspirin can cause either hypo- or hyperglycemia. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: (Moderate) Use large doses of aspirin cautiously in patients receiving insulin. Per ulteriori informazioni su questo medicinale, contatti il rappresentante locale del titolare. Because blood glucose may be lowered by the use of chromium, patients who are on antidiabetic agents may need dose adjustments. La penna contenente la cartuccia non deve essere, mg) di insulina lispro. After acute overdose, aspirin can cause either hypo- or hyperglycemia. Azilsartan; Chlorthalidone: (Moderate) Monitor patients receiving angiotensin II receptor antagonists concomitantly with insulin for changes in glycemic control. Also, adrenergic medications may decrease glucose uptake by muscle cells. For treatment of cold symptoms, nasal decongestants may be preferable for short term, limited use (1 to 3 days) as an alternative to systemic decongestants in patients taking medications for diabetes. Può somministrarsi da 1 a 80 unità per singola iniezione. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. Corticosteroids stimulate hepatic glucose production and inhibit peripheral glucose uptake into muscle and fatty tissues, producing insulin resistance. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Pioglitazone should be discontinued if any deterioration in cardiac status occurs. The cardiovascular events were noted at doses of both 4 mg/day and 8 mg/day of rosiglitazone. Non la faccia cadere e non la faccia urtare contro superfici dure. I casi gravi di allergia generalizzata possono mettere in. An increased risk for hypoglycemia is possible. Per maggiori informazioni sulla terapia con Insulin lispro Sanofi, leggere il. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion. Atazanavir; Cobicistat: (Moderate) Monitor patients receiving insulin closely for changes in diabetic control, specifically hyperglycemia, when anti-retroviral protease inhibitors are instituted. However, once any insulin has been withdrawn from a cartridge using a syringe, that cartridge should not be used in an insulin pen device because the inadvertent introduction of air into the cartridge can alter the pen's mechanics resulting in inaccurate dosing. In addition, diuretics reduce the risk of stroke and cardiovascular disease in patients with diabetes. In large doses, salicylates uncouple oxidative phosphorylation, deplete hepatic and muscle glycogen, and cause hyperglycemia and glycosuria. Patients who are taking antidiabetic agents should monitor for worsening glycemic control when a phenothiazine is instituted. Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol (or equivalent) per day in combined oral contraceptives (COCs), which are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings. Insulin lispro Sanofi - Diabete mellito - Farmaci usati nel diabete, - Per il trattamento di adulti e bambini con diabete mellito che necessitano di insulina pe Somministrazione endovenosa di Insulina lispro Sanofi, L’iniezione endovenosa di insulina lispro deve essere effettuata seguendo la normale pratica clinica, per le somministrazioni endovenose, per esempio mediante bolo endovenoso o tramite un dispositivo. Togliere, 3. Many non-prescription drug products may be formulated with alcohol; instruct patients to scrutinize product labels prior to consumption. Un’ipoglicemia grave può portare a perdita, di conoscenza e, in casi molto estremi, alla morte. Insulin lispro Sanofi European Union - Italian - EMA (European Medicines Agency) Buy It Now. Un ml di soluzione contiene 100 unità (equivalenti a 3,5, mg) di insulina lispro. Smaltisca l’ago usato in un contenitore per oggetti taglienti o come indicato dal farmacista o. Utilizzi la penna solo entro i 28 giorni dal primo utilizzo. Because of this, a potential pharmacodynamic interaction exists between these drugs and all antidiabetic agents. Pegvisomant increases sensitivity to insulin by lowering the activity of growth hormone, and in some patients glucose tolerance improves with treatment. Contiene il principio attivo insulina, Insulin lispro Sanofi è un “medicinale biosimilare”. Inhibitors of MAO type A have been shown to prolong the hypoglycemic response to insulins. Per the manufacturer, insulin and pramlintide should not be combined in the same syringe or administered in the same injection site as the pharmacokinetic parameters of pramlintide are altered by regular, isophane (NPH), and premixed 70/30 insulin formulations; however, in a randomized, open-label crossover study in type 1 diabetes patients, the pharmacokinetics, pharmacodynamics, and safety of 30 mcg of pramlintide were not changed significantly when mixed with various short-acting insulins, long-acting insulins, or both immediately before injection. Possible mechanisms include atypical antipsychotic-induced insulin resistance or direct beta-cell inhibition. Chlorpheniramine; Pseudoephedrine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. In addition, diuretics reduce the risk of stroke and cardiovascular disease in patients with diabetes. Both hyperglycemia and hypoglycemia have been described in patients treated with acetazolamide. Articaine; Epinephrine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Idrossido di sodio o acido cloridrico possono essere aggiunti. Valutazione clinica e metabolica dell’impiego dell’insulina Lispro in pazienti con diabete mellito scompensato. Onset averaged approximately 63 days after initiating protease inhibitor therapy, but has occurred as early as 4 days after beginning therapy. (Moderate) Monitor patients receiving insulin closely for changes in diabetic control when thiazide diuretics are instituted or discontinued; dosage adjustments may be required. To manage hypoglycemic risk, lower doses of insulin may be needed. Indipendentemente dalla sede d’iniezione permane una comparsa di attività più, veloce rispetto all’insulina umana solubile. Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. In clinical trials, lorcaserin use was associated with reports of hypoglycemia. Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas. Selective beta-blockers, such as atenolol or metoprolol, do not appear to potentiate insulin-induced hypoglycemia. Per il caricamento della cartuccia, l’inserimento, dell’ago e la somministrazione dell’insulina, si consiglia di seguire le istruzioni del produttore fornite. Propoxyphene: (Moderate) Propoxyphene may enhance the hypoglycemic action of antidiabetic agents. Patients at risk include those with compromised renal function, those fasting for prolonged periods, those that are malnourished, and those receiving high or excessive doses of sulfonamides. una eccessiva (sovradosaggio) perché l’ago potrebbe bloccarsi. Selective beta-blockers, such as atenolol or metoprolol, do not appear to potentiate insulin-induced hypoglycemia. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Essendosi assicurati che la punta dell’ago sia nell’insulina. RIASSUNTO DELLE CARATTERISTICHE DEL PRODOTTO, nuove informazioni sulla sicurezza. To manage hypoglycemic risk, lower doses of insulin may be needed. Interazioni con altri medicinali ed altre forme d’interazione, Il fabbisogno di insulina può aumentare per la co-somministrazione di prodotti medicinali con attività, iperglicemizzante come i contraccettivi orali, i corticosteroidi o durante terapia sostitutiva con ormoni. rapidi rispetto all’insulina umana solubile. Epinephrine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Dimensione della confezione: 1 o 5 flaconcini. For treatment of cold symptoms, nasal decongestants may be preferable for short term, limited use (1 to 3 days) as an alternative to systemic decongestants in patients taking medications for diabetes. Methylprednisolone: (Moderate) Monitor patients receiving insulin closely for worsening glycemic control when corticosteroids are instituted and for signs of hypoglycemia when corticosteroids are discontinued. Acrivastine; Pseudoephedrine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Tenga la penna in uso a temperatura ambiente. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion. Per prevenire la possibile trasmissione di patologie, ciascuna cartuccia deve essere utilizzata da un. Ethinyl Estradiol; Norethindrone Acetate: (Minor) Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. To manage hypoglycemic risk, lower doses of insulin may be needed. Cortisone: (Moderate) Monitor patients receiving insulin closely for worsening glycemic control when corticosteroids are instituted and for signs of hypoglycemia when corticosteroids are discontinued. Insulina lispro Sanofi soluzione iniettabile in penna preriempita (SoloStar). Mometasone: (Moderate) Monitor patients receiving insulin closely for worsening glycemic control when corticosteroids are instituted and for signs of hypoglycemia when corticosteroids are discontinued. Dosage adjustments may be necessary. Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas. For women with persistent fasting and postprandial hyperglycemia after most meals, initial suggested total daily insulin requirements are roughly 0.7 to 1 units/kg/day. Another possible mechanism is impairment of beta-cell function. Metformin; Pioglitazone: (Moderate) Coadministration of metformin with an insulin may increase the risk of hypoglycemia. Amoxicillin; Clarithromycin; Lansoprazole: (Moderate) The concomitant use of clarithromycin and insulin or other antidiabetic agents can result in significant hypoglycemia. Pertanto, il CHMP ha ritenuto che, come nel caso di Humalog, i benefici, siano superiori ai rischi individuati e ha raccomandato il rilascio dell’autorizzazione all’immissione in, Quali sono le misure prese per garantire l’uso sicuro ed efficace di Insulin, Le raccomandazioni e le precauzioni che gli operatori sanitari e i pazienti devono osservare affinché, Insulin lispro Sanofi sia usato in modo sicuro ed efficace sono state riportate nel riassunto delle. È possibile che. Hydrochlorothiazide, HCTZ; Metoprolol: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. Possible mechanisms include atypical antipsychotic-induced insulin resistance or direct beta-cell inhibition. Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may decrease antidiabetic agent dosage requirements. Di norma deve iniettarsi Insulina lispro Sanofi entro i 15 minuti precedenti un. dietetico e l’attività fisica del paziente. Codeine; Phenylephrine; Promethazine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. For treatment of cold symptoms, nasal decongestants may be preferable for short term, limited use (1 to 3 days) as an alternative to systemic decongestants in patients taking medications for diabetes. Thus, salicylates can decrease blood glucose concentrations. Onset averaged approximately 63 days after initiating protease inhibitor therapy, but has occurred as early as 4 days after beginning therapy. This prevents contamination of the remaining insulin lispro in the vial by the NPH insulin.Do not mix Admelog or Lyumjev with any other insulins. Amiloride; Hydrochlorothiazide, HCTZ: (Moderate) Monitor patients receiving insulin closely for changes in diabetic control when thiazide diuretics are instituted or discontinued; dosage adjustments may be required. For treatment of cold symptoms, nasal decongestants may be preferable for short term, limited use (1 to 3 days) as an alternative to systemic decongestants in patients taking medications for diabetes. Decreased insulin production may occur in the pancreas due to a direct effect on pancreatic beta cells. Because of this, a potential pharmacodynamic interaction exists between these drugs and all antidiabetic agents. Ripeta ogni volta esattamente le stesse operazioni. Non congelare. In uno, studio crossover in doppio cieco, la riduzione dei livelli di emoglobina glicosilata dopo 12 settimane di, trattamento è stata di 0,37 punti percentuali con insulina lispro rispetto a 0,03 punti percentuali con, Studi clinici in pazienti con diabete di tipo 2, trattati con sulfoniluree alle massime dosi, hanno, mostrato che l’aggiunta di insulina lispro riduce in modo significativo la HbA1c rispetto all’uso di, sulfonilurea da sola. Continuous Subcutaneous Insulin Infusion (CSII)Preparation and Pump SelectionDo not mix insulin lispro with other insulins or diluents when using an external pump.Do NOT administer Humalog U-200 using a continuous subcutaneous infusion pump. After acute overdose, aspirin can cause either hypo- or hyperglycemia. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. In alcune circostanze, ad, esempio quando i livelli di acidi nel sangue sono pericolosamente elevati (chetoacidosi), il medicinale, Poiché Insulin lispro Sanofi è un’insulina ad azione rapida, viene generalmente somministrata subito, prima di un pasto e, quando necessario, subito dopo un pasto. Carbinoxamine; Dextromethorphan; Pseudoephedrine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Quando viene impiegato con una pompa per infusione di. Minor, local sensitivity characterized by redness, swelling, or itching at the site of injection does not usually contraindicate therapy. Beta-blockers also exert complex actions on the body's ability to regulate blood glucose. To prevent fetal and maternal complications, meticulous blood glucose control and monitoring is required. hanno dato risultati significativi in merito alla tossicità. numero di unità è visibile nella finestrella di dosaggio, lo controlli sempre prima dell’iniezione. Pasireotide inhibits the secretion of insulin and glucagon. In addition, ACE inhibitors have been associated with a reduced incidence in the development of new-onset diabetes in patients with hypertension or other cardiac disease. Chieda assistenza se ha problemi a gestire la penna, per esempio se ha problemi di vista. Come accade con tutte le preparazioni di insulina, l’andamento temporale dell’azione di insulina lispro. Ethinyl Estradiol; Norelgestromin: (Minor) Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. Systemic and inhaled corticosteroids are known to increase blood glucose and worsen glycemic control in patients taking antidiabetic agents. Salicylates, by inhibiting prostaglandin E2 synthesis, can indirectly increase insulin secretion. Diphenhydramine; Hydrocodone; Phenylephrine: (Moderate) Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Si assicuri che la sua confezione di Insulina lispro Sanofi, medico. Changes in glucose tolerance occur more commonly in patients receiving 50 mcg or more of ethinyl estradiol (or equivalent) per day in combined oral contraceptives (COCs), which are not commonly used in practice since the marketing of lower dose COCs, patches, injections and rings. In addition to insulin administration, adequate fluid therapy must be initiated (usually 0.45% or 0.9% Sodium Chloride infusion, fluid type and hourly requirements based on estimated patient need and serum osmolality). Tacrolimus: (Moderate) Tacrolimus has been reported to cause hyperglycemia. Use Admelog or Humalog 100 units/mL only. In 40 patients with DKA, 20 patients each were randomized to either insulin lispro 0.3 units/kg subcutaneously followed by 0.1 units/kg subcutaneously every 1 hour or regular insulin 0.1 units/kg IV bolus followed by 0.1 units/kg/hour by continuous IV infusion. Treatment with subcutaneous insulin lispro has been shown to be an effective alternative to the use of intravenous regular insulin in the treatment of mild and moderate DKA; however, patients with severe DKA should be managed with intravenous insulin infusion in the ICU. Empagliflozin; Metformin: (Moderate) Coadministration of metformin with an insulin may increase the risk of hypoglycemia. prevenire miscele accidentali fra Insulina lispro Sanofi e altri prodotti a base di insulina. Ethinyl Estradiol; Ethynodiol Diacetate: (Minor) Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. Si assicuri che la sua confezione di Insulina, lispro Sanofi corrisponda a quella che il, medico. The hypoglycemic effect induced by IGF-1 activity may be exacerbated. (Minor) Progestins can decrease the hypoglycemic effects of antidiabetic agents by impairing glucose tolerance. Insulin lispro Sanofi - Diabete mellito - Farmaci usati nel diabete, - Per il trattamento di adulti e bambini con diabete mellito che necessitano di insulina per il mantenimento dell'omeostasi glicemica normale. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. Corticosteroids stimulate hepatic glucose production and inhibit peripheral glucose uptake into muscle and fatty tissues, producing insulin resistance. (Minor) Progestins can decrease the hypoglycemic effects of antidiabetic agents by impairing glucose tolerance. Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. Tenere la penna preriempita nell’imballaggio esterno per proteggere il medicinale dalla luce. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion. Also, adrenergic medications may decrease glucose uptake by muscle cells. Selective beta-blockers, such as atenolol or metoprolol, do not appear to potentiate insulin-induced hypoglycemia. Hypoglycemia is the most common adverse effect of insulin therapy; hypoglycemia is the major barrier to achieving optimal glycemic control long term. Define insulin lispro. Another possible mechanism is impairment of beta-cell function. Brimonidine; Timolol: (Moderate) Increased frequency of blood glucose monitoring may be required when a beta blocker is given with antidiabetic agents. rivolga al medico o al farmacista. For treatment of cold symptoms, nasal decongestants may be preferable for short term, limited use (1 to 3 days) as an alternative to systemic decongestants in patients taking medications for diabetes. After acute overdose, aspirin can cause either hypo- or hyperglycemia. 3. Use Admelog or Humalog 100 units/mL only to prepare infusions. The presence or absence of a concomitant progestin may influence the significance of any hormonal effect on glucose homeostasis. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion. Italian - According to OBRA, the use of antidiabetic medications should include monitoring (e.g., periodic blood glucose) for effectiveness based on desired goals for that individual and to identify complications of treatment such as hypoglycemia or impaired renal function.[60742]. Do NOT administer Humalog 200 units/mL intravenously. Also, adrenergic medications may decrease glucose uptake by muscle cells. (Moderate) Monitor patients receiving insulin closely for changes in diabetic control when thiazide diuretics are instituted or discontinued; dosage adjustments may be required. Patients at risk include those with compromised renal function, those fasting for prolonged periods, those that are malnourished, and those receiving high or excessive doses of sulfonamides. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents. Thiazide diuretics can decrease the hypoglycemic effects of insulin by producing an increase in blood glucose levels. Systemic and inhaled corticosteroids are known to increase blood glucose and worsen glycemic control in patients taking antidiabetic agents. Since beta blockers inhibit the release of catecholamines, these medications may hide symptoms of hypoglycemia such as tremor, tachycardia, and blood pressure changes. Aggravation of diabetes mellitus has been reported. Insulina lispro Sanofi in flaconcino è disponibile in una confezione da 1 o 5 flaconcini. Può inoltre segnalare gli effetti indesiderati direttamente tramite il sistema, nazionale di segnalazione riportato nell’Allegato V. Segnalando gli effetti indesiderati può contribuire. (Moderate) Monitor patients receiving insulin closely for changes in diabetic control when thiazide diuretics are instituted or discontinued; dosage adjustments may be required. Carbonic anhydrase inhibitors: (Minor) Carbonic anhydrase inhibitors may alter blood sugar. It appears that the effects of thiazide diuretics on glycemic control are dose-related and low doses can be instituted without deleterious effects on glycemic control. Other symptoms, like headache, dizziness, nervousness, mood changes, or hunger are not blunted. Thyroid hormones are important in the regulation of carbohydrate metabolism, gluconeogenesis, the mobilization of glycogen stores, and protein synthesis. Monitor for loss of glycemic control when pseudoephedrine, phenylephrine, and other sympathomimetics are administered to patients taking antidiabetic agents.